What Is Spectinomycin Sulfate Powder?

Spectinomycin sulfate powder is a broad-spectrum antibiotic belonging to the aminocyclitol class. It is primarily used in veterinary and human medicine to treat bacterial infections, particularly those caused by Gram-negative and some Gram-positive bacteria. Its unique mechanism of action and low toxicity make it a valuable therapeutic option in specific clinical scenarios.

Chemical Properties

Spectinomycin sulfate is the sulfate salt form of spectinomycin, derived from Streptomyces spectabilis. It appears as a white to off-white crystalline powder, highly soluble in water but poorly soluble in organic solvents. The chemical formula is C₁₄H₂₄N₂O₇·H₂SO₄, and its molecular weight is 495.48 g/mol.

Mechanism of Action

Spectinomycin inhibits bacterial protein synthesis by binding to the 30S subunit of the bacterial ribosome, preventing the elongation of peptide chains. Unlike other aminoglycosides, it does not cause misreading of mRNA, making it bacteriostatic rather than bactericidal at typical doses.

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Clinical Applications Of Spectinomycin Sulfate Tetrahydrate

Human Medicine

Primarily used to treat gonorrhea (especially penicillin-resistant Neisseria gonorrhoeae).

An alternative for patients allergic to β-lactams or cephalosporins.

Sometimes used in traveler’s diarrhea caused by susceptible strains.

Veterinary Medicine

Effective against respiratory and enteric infections in poultry, swine, and cattle.

Commonly used in combination with other antibiotics (e.g., lincomycin) for enhanced efficacy.

Dosage and Administration

Humans: Typically administered as a single intramuscular (IM) injection (2 g for gonorrhea).

Animals: Mixed in drinking water or feed (dosage varies by species and infection severity).

Advantages

Low toxicity compared to other antibiotics (minimal ototoxicity or nephrotoxicity).

Effective against resistant strains of bacteria.

Well-tolerated in both humans and animals.

Side Effects

Rare but may include dizziness, nausea, or pain at the injection site.

Hypersensitivity reactions in sensitive individuals.

Spectinomycin sulfate VS spectinomycin hydrochloride

Spectinomycin hydrochloride is another salt form of spectinomycin hydrochloride. Spectinomycin sulfate and spectinomycin hydrochloride are two common salt forms of the antibiotic spectinomycin, which is an aminocyclitol antibiotic used primarily to treat infections caused by susceptible bacteria, including gonorrhea. The key difference between them lies in their chemical composition, solubility, stability, and potential applications. Here’s a comparison:

1. Chemical Composition
Spectinomycin sulfate: Formed by combining spectinomycin with sulfuric acid (H₂SO₄).

Chemical formula: C₁₄H₂₄N₂O₇ · H₂SO₄

Spectinomycin hydrochloride: Formed by combining spectinomycin with hydrochloric acid (HCl).

Chemical formula: C₁₄H₂₄N₂O₇ · HCl

2. Solubility
Spectinomycin sulfate: Generally more soluble in water compared to the hydrochloride form.

Spectinomycin hydrochloride: Slightly less soluble but still sufficiently soluble for pharmaceutical formulations.

3. Stability & pH
The sulfate form tends to be more stable in solution, which may be preferable for long-term storage.

The hydrochloride form may have a slightly different pH in solution, which could affect compatibility with other compounds.

4. Pharmaceutical Use
Spectinomycin sulfate is more commonly used in veterinary medicine and some human formulations.

Spectinomycin hydrochloride is also used but may be preferred in specific formulations where chloride salts are more compatible.

5. Potency & Dosage
The molecular weight difference between sulfate and hydrochloride affects the equivalent dose of active spectinomycin.

Sulfate salt: Higher molecular weight → slightly lower % of active spectinomycin per mg.

Hydrochloride salt: Lower molecular weight → slightly higher % of active spectinomycin per mg.

Adjustments may be needed when switching between salts to ensure equivalent antibiotics activity.

6. Regulatory & Commercial Availability
Spectinomycin sulfate is more widely available in certain markets (e.g., veterinary use).

Spectinomycin hydrochloride may be used in specific injectable or oral formulations.

Conclusion
Both forms are effective as antibiotics, but the choice depends on:

Solubility needs (sulfate is more soluble).

Formulation stability (sulfate may be more stable).

Regulatory and manufacturing preferences.

For medical or veterinary use, the specific salt form should be chosen based on the intended formulation and pharmacokinetic requirements.

Where to buy spectinomycin sulfate powder ?

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Conclusion

Spectinomycin sulfate powder remains a critical antibiotic in specific therapeutic areas, particularly for drug-resistant infections. Its safety profile and efficacy ensure its continued use in both human and veterinary medicine. However, prudent use is necessary to prevent antibiotic resistance.

Reference:

https://pubchem.ncbi.nlm.nih.gov/compound/Spectinomycin-sulfate-tetrahydrate#section=Chemical-and-Physical-Properties

Package:

1.1-5kg sample order we can provide aluminum foil bag package.

2.5-10kg order we can provide aluminum foil bag package.

3.Normally a full packge is 25kg/drum or 25kg/bag or 25kg/carton.

Contacts:

E-Mail:sales@naturallifeworth.com

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