What is Niclosamide?

Niclosamide is a chlorinated salicylanilide compound first approved in the 1960s by the FDA as an oral anthelmintic agent. It is listed on the World Health Organization’s List of Essential Medicines. It is highly effective against Taenia saginata (beef tapeworm), Taenia solium (pork tapeworm), and Diphyllobothrium latum (fish tapeworm). However, recent research has revealed its potential in treating a variety of other conditions, including cancer, bacterial and viral infections, and metabolic disorders. With continued in-depth research, its application will become more and more widespread.

Chemical Properties of Niclosamide

Niclosamide (chemical name: 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide) is a salicylanilide derivative with the molecular formula C₁₃H₈Cl₂N₂O₄. It appears as a yellowish-white powder that is practically insoluble in water but soluble in organic solvents such as ethanol, dimethyl sulfoxide (DMSO), and acetone.

Key Chemical Characteristics:

Molecular Weight: 327.12 g/mol

Melting Point: 225–230°C

Solubility: Poor aqueous solubility (improved via salt formation or nanoparticle formulations)

Stability: Stable under recommended storage conditions (room temperature, protected from light and moisture)

Due to its poor water solubility, researchers have explored various formulations (e.g., nanoparticles, liposomes, and solid dispersions) to enhance bioavailability.

Mechanism of Action

Niclosamide exerts its effects through multiple pathways, making it a versatile therapeutic agent.

1. Anthelmintic Activity

Niclosamide primarily works against tapeworms by:

Inhibiting oxidative phosphorylation in mitochondria, disrupting ATP production.

Paralyzing the worm’s musculature, leading to detachment from the intestinal wall.

Increasing susceptibility to digestive enzymes, resulting in the worm’s disintegration.

1. Anticancer Effects

Recent studies indicate niclosamide’s potential in cancer therapy by targeting:

Wnt/β-catenin signaling (a pathway involved in tumor growth).

mTOR and STAT3 pathways (critical for cancer cell proliferation).

Inducing apoptosis (programmed cell death) in various cancer cell lines.

1. Antiviral and Antibacterial Properties

Antiviral: Niclosamide inhibits SARS-CoV-2 replication by interfering with pH-dependent viral entry and endosomal maturation. It also shows activity against Zika, Ebola, and other viruses.

Antibacterial: It disrupts bacterial biofilms and combats drug-resistant strains like MRSA.

1. Metabolic and Anti-inflammatory Effects

Modulates AMPK signaling, improving insulin sensitivity (potential for diabetes treatment).

Suppresses NF-κB, reducing inflammation in autoimmune diseases.

Where to Buy 99% Pure Niclosamide Powder

Our Lifeworth is a professional supplier and manufacturer for Niclosamide, our company covers an area of 130 acres, has 10 production lines, specializing in the production of Niclosamide raw materials and preparations, we can supply bulk bp 99% Pure Niclosamide Powder, 99% Niclosamide Ethanolamine Salt, 99% Niclosamide Piperazine, the annual output of Niclosamide products exceeds 20000 tons. The main products we supply include streptomycin sulfate, colistin sulfate, spectinomycin hydrochloride, spectinomycin sulfate, neomycin sulfate, colistin sulfate premix, nisin, etc., all of which meet the cp bp ep usp standards. Our company has passed GMP certification and EU CEP certification, and some products have passed German EU-GMP certification, US FDA certification, and sterile CEP certification. The total supply of antibiotic products exceeds 60,000 tons per year. At present, the products have been exported to more than 80 countries around the world, including North America, Europe, Asia, South Africa, etc., and the product quality has always been recognized by customers. Our product inventory is stable and the price is competitive. We hope to discuss cooperation with you.

If you want to buy bulk 99% Pure Niclosamide Powder,kindly contact us:sales@naturallifeworth.com, we will help you.

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How is Niclosamide Produced?

Pure Niclosamide is synthesized through a multi-step organic process involving several chemical reactions. The production process typically includes the following steps:

Nitration: A phenolic compound is nitrated using nitric acid to introduce a nitro group (-NO2).

Chlorination: The phenolic compound is then treated with a chlorinating agent to substitute chlorine atoms at specific positions in the molecule.

Amidation: The chlorinated compound is reacted with an amine to form the amide structure, which completes the Niclosamide molecule.

Once the synthesis is complete, the resulting Niclosamide is purified to achieve a high purity level of 99%, which is crucial for pharmaceutical and research applications. The powder form is then dried and processed to create the final product—99% pure Niclosamide powder.

Applications of 99% pure Niclosamide powder

Antiparasitic Treatment

Niclosamide’s most well-known application is its use as an anthelmintic drug to treat tapeworm infections, such as Taenia saginata (beef tapeworm) and Diphyllobothrium latum (fish tapeworm). It is highly effective in paralyzing and killing adult tapeworms in the intestines without being absorbed into the bloodstream.

Antiviral Potential

Recent studies have shown that Niclosamide exhibits antiviral activity, particularly against emerging viral infections such as COVID-19. Researchers have found that Niclosamide inhibits viral replication by disrupting viral processes in the host cells, making it a potential candidate for repurposing as an antiviral agent.

Cancer Treatment

Pure Niclosamide powder is being investigated for its ability to inhibit several signaling pathways involved in cancer cell growth, including the Wnt/β-catenin and mTOR pathways. Preclinical studies have demonstrated that Niclosamide can induce apoptosis (programmed cell death) in cancer cells, offering hope for its use in oncology.

Treatment of Metabolic Disorders

In addition to its antiparasitic and antiviral properties, Niclosamide has been shown to have anti-diabetic and anti-obesity effects. Studies suggest that Niclosamide may improve insulin sensitivity and promote weight loss by targeting metabolic pathways, such as AMPK activation.

Anti-inflammatory Effects

99% pure Niclosamide powder has shown promise in reducing inflammation through its ability to modulate inflammatory pathways. This makes it a potential therapeutic option for conditions characterized by chronic inflammation, such as autoimmune diseases and inflammatory bowel disease (IBD).

Benefits of 99% Pure Niclosamide Powder

Using 99% pure Niclosamide powder offers several key benefits, particularly in pharmaceutical formulations and research settings:

High Efficacy: The high purity ensures the drug’s effectiveness in treating infections and other conditions.

Consistency in Research: For laboratory research, the consistent purity of 99% ensures reproducible results in experiments.

Versatile Applications: Niclosamide is useful for not only parasitic infections but also for a wide range of potential applications in antiviral therapy, cancer treatment, and metabolic disorders.

Conclusion

99% pure Niclosamide powder is an important pharmaceutical compound with proven efficacy in treating parasitic infections and emerging potential in the treatment of cancer, viral diseases, and metabolic disorders. With its high purity and versatile applications, Niclosamide remains a valuable asset in both clinical and research fields.

As research continues to explore the broader uses of Niclosamide, its significance is likely to expand, offering new therapeutic options for a variety of diseases. Reputable manufacturers like Lifeworth ensure that Niclosamide powder meets the highest quality standards, making it suitable for both established and innovative applications.

Reference:

https://en.wikipedia.org/wiki/Niclosamide

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5628105/

Package:

1.1-5kg sample order we can provide aluminum foil bag package.

2.5-10kg order we can provide aluminum foil bag package.

3.Normally a full packge is 25kg/drum or 25kg/bag or 25kg/carton.

Contacts:

E-Mail: sales@naturallifeworth.com
Mobile: 0086-18292562757
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