What is Ampicillin Sodium Salt Powder?

Ampicillin Sodium Salt is a semi-synthetic penicillin antibiotic widely used in both clinical and research settings. As the sodium salt form of ampicillin, it offers enhanced solubility in water, making it suitable for intravenous (IV) or intramuscular (IM) administration.

Chemical Properties

Ampicillin Sodium Salt (C₁₆H₁₈N₃NaO₄S) is a white or off-white crystalline powder with high water solubility. Its molecular weight is 371.39 g/mol, and it is derived from the beta-lactam antibiotic ampicillin. The sodium salt formulation improves stability and bioavailability, facilitating its use in injectable solutions.

Mechanism of Action

As a beta-lactam antibiotic, Ampicillin Sodium Salt inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs). This action disrupts peptidoglycan cross-linking, leading to osmotic instability and bacterial cell lysis. It is effective against both Gram-positive and some Gram-negative bacteria, including:

Streptococcus pneumoniae

Haemophilus influenzae

Escherichia coli

Proteus mirabilis

Salmonella spp.

Unlike natural penicillins, ampicillin exhibits a broader spectrum due to its ability to penetrate the outer membrane of certain Gram-negative bacteria.

The manufacturer of Pure Ampicillin Sodium Salt Powder USP BP EP

Our Lifeworth is a professional supplier & manufacturer for Ampicillin Sodium Salt,our company has passed GMP certification and EU CEP certification, and some products have passed German EU-GMP certification, US FDA certification, and sterile CEP certification.Our company has 7 production lines dedicated to the production of Ampicillin Sodium Salt , we can supply Pure Ampicillin Sodium Salt BP EP USP bulk 99% ,with an annual output of more than 4,500 tons of Ampicillin Sodium Salt .The product has been exported to more than 80 countries around the world, including North America, Europe, Asia, South Africa, etc.,the product quality has always been recognized by customers.

In addition to Pure Ampicillin Sodium Salt Powder,we also can supply Taymycin fumarate powder 99%, pure ciprofloxacin lactate powder,pure Ciprofloxacin Hydrochloride powder,USP BP Amoxicillin Trihydrate Powder, 99% pure ampicillin, pure ivermectin powder, ampicillin sodium, erythromycin, penicillin powder, azithromycin, and other products. The quality of our products meets the BP EP USP standard, and the annual output of antibiotic products exceeds 80,000 tons. Our production capacity and product quality are stable, and our product prices are competitive in the market,our products have a great influence in the international market.

If you want to buy Pure Ampicillin Sodium Salt bulk, but you don’t know where to buy it, kindly contact us:sales@naturallifeworth.com, we will help you.

The Specification of Amoxicillin Sodium

The Production Process of Ampicillin Sodium Salt Powder

The production of Ampicillin Sodium Salt Powder follows a meticulous process that ensures the purity, stability, and potency of the final product. The manufacturing process involves several key steps:

Synthesis of Ampicillin: The process begins with the synthesis of ampicillin, which is derived from 6-aminopenicillanic acid (6-APA). The chemical structure of ampicillin is altered to enhance its ability to combat bacterial infections, offering an extended spectrum of activity compared to natural penicillins.

Formation of Sodium Salt: The ampicillin is then reacted with sodium hydroxide or sodium bicarbonate to form the sodium salt. This step is crucial as it enhances the solubility of the compound in water, making it suitable for intravenous administration.

Purification: The resulting mixture is purified to remove any impurities or by-products from the reaction. The purification process includes filtration, crystallization, and drying, which ensures that only pure Ampicillin Sodium Salt is present in the final powder form.

Quality Control and Testing: The powder undergoes a series of tests to ensure that it meets the required specifications for purity, potency, and sterility. This involves high-performance liquid chromatography (HPLC) and microbiological testing to confirm its safety and efficacy.

Packaging: After passing the necessary quality control checks, the Ampicillin Sodium Salt Powder is packaged in sterile containers and prepared for distribution.

The entire production process is carefully controlled to meet international pharmaceutical standards, ensuring that the end product is both effective and safe for use.

Efficacy of Ampicillin Sodium Salt Powder

Ampicillin Sodium Salt Powder is known for its broad-spectrum antibacterial properties. Its primary mechanism of action is the inhibition of bacterial cell wall synthesis, which results in the death of the bacteria. It is effective against a wide variety of infections caused by both Gram-positive and Gram-negative bacteria.

The powder form of ampicillin is highly soluble in water, allowing it to be quickly absorbed by the body when administered intravenously or intramuscularly. This quick absorption makes it ideal for treating acute infections where rapid action is needed.

Some of the key bacteria that Ampicillin Sodium Salt Powder is effective against include:

Escherichia coli (E. coli)

Streptococcus pneumoniae

Haemophilus influenzae

Neisseria gonorrhoeae

Proteus mirabilis

Salmonella species

Ampicillin Sodium Salt is also effective in treating respiratory tract infections, urinary tract infections, skin infections, and infections of the gastrointestinal tract.

However, it is important to note that resistance to ampicillin, like other antibiotics, has been observed in certain bacterial strains. Therefore, careful use and appropriate diagnostic testing are necessary to ensure its continued effectiveness.

Applications of Ampicillin Sodium Salt Powder

Ampicillin Sodium Salt Powder is primarily used in the treatment of bacterial infections. Its applications are vast and varied, as it can be used to treat a range of infections caused by susceptible organisms. Some of the key therapeutic areas where it is applied include:

Respiratory Tract Infections: This includes conditions like pneumonia, bronchitis, and upper respiratory infections caused by bacteria susceptible to ampicillin.

Urinary Tract Infections (UTIs): Ampicillin is commonly used to treat urinary tract infections caused by bacteria like E. coli and Proteus species.

Gastrointestinal Infections: It is effective against infections such as Salmonella and Shigella, which can affect the gastrointestinal tract.

Sepsis and Meningitis: In more severe cases, Ampicillin Sodium Salt is often administered intravenously to treat life-threatening conditions like sepsis and meningitis caused by susceptible bacteria.

Endocarditis: This serious infection of the heart valves can be treated with ampicillin in combination with other antibiotics.

Ampicillin is also used in the prevention of infections during surgical procedures, especially in patients who may be at higher risk of post-operative infections.

Market Overview of Ampicillin Sodium Salt Powder

The global market for antibiotics is growing steadily, and Ampicillin Sodium Salt Powder plays a significant role in this market. As one of the most widely used antibiotics, its demand remains high, especially in developing regions where bacterial infections are a leading cause of morbidity and mortality.

The market for Ampicillin Sodium Salt Powder is driven by factors such as:

Rising incidence of bacterial infections: The increasing prevalence of infections like pneumonia, urinary tract infections, and sepsis is driving the demand for effective antibiotics.

Availability of generic alternatives: Ampicillin is available in generic forms, making it affordable and accessible to a larger population.

Hospital and healthcare infrastructure growth: The expansion of healthcare facilities, particularly in emerging markets, contributes to increased use of antibiotics in both preventive and therapeutic settings.

However, the rise of antibiotic resistance is a growing concern that may impact the market for ampicillin. This has led to an increased focus on the development of new antibiotics and alternative therapies. Regulatory policies in different countries also influence the market dynamics, particularly in terms of approval processes and pricing.

Conclusion

Ampicillin Sodium Salt Powder is a broad-spectrum, water-soluble antibiotic widely applied in human medicine, veterinary products, and biotechnology research. Its sodium form ensures stability and fast absorption, making it a preferred choice for injectable and oral drug formulations.

For businesses seeking high-quality bulk supply, Lifeworth is a trusted manufacturer and supplier of Ampicillin Sodium Salt Powder, providing premium-grade raw materials to meet global market needs.

Reference:

https://www.webmd.com/drugs/2/drug-1443/ampicillin-injection/details

https://pubchem.ncbi.nlm.nih.gov/compound/Ampicillin-Sodium

Package:

1.1-5kg sample order we can provide aluminum foil bag package.

2.5-10kg order we can provide aluminum foil bag package.

3.Normally a full packge is 25kg/drum or 25kg/bag or 25kg/carton.

Contacts:

E-Mail: sales@naturallifeworth.com
Mobile: 0086-18292562757
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