What is oxytetracycline injectable?

The raw material of oxytetracycline injectable is a light yellow or yellow crystalline powder that is easily soluble in water. It is sensitive to light and heat and needs to be sealed, darkened, and stored in a dry place. The quality of the raw material must comply with the standards of BP EP USP CP ect.The main inspection indicators include:

Assay (generally oxytetracycline hydrochloride):purity is more than 99%.

Related substance control

Microbial limit test

Sterility and pyrogen test (for injection preparations):bacterial endotoxins meet the requirements

Specification

inj oxytetracycline production process

Fermentation production

Oxytetracycline is mainly produced by fermentation of Streptomyces rimosus, and the process includes:

Strain culture: Optimize the strain to improve the yield.

Fermentation stage: Control the temperature (26-28℃), pH (6.0-6.5) and dissolved oxygen content in large fermenters.

Extraction and purification:

After acidification and filtration, the fermentation broth is extracted with an organic solvent (such as butanol).

Further purification is performed by crystallization or chromatography.

Drying and packaging: Spray drying or vacuum drying to ensure that the moisture content is ≤1.0%.

Key process control points

Fermentation optimization: The ratio of carbon source (such as starch) and nitrogen source (such as soybean meal) affects the yield.

Impurity control: Degradation products such as 4-dimorphic oxytetracycline need to be removed.

Aseptic processing: Injection-grade raw materials need to be terminally sterilized or aseptically filtered.

Indications and Uses

Sterile oxytetracycline inj powder is commonly prescribed for:

Respiratory infections (e.g., pneumonia in cattle and swine)

Bacterial enteritis (e.g., caused by E. coli or Salmonella)

Mastitis in dairy cattle

Foot rot and metritis in livestock

Contagious bovine pleuropneumonia (CBPP)

Anthrax and other systemic infections

Dosage and Administration

The dosage varies depending on the animal species, weight, and severity of infection. A typical dosage range is 5–20 mg/kg body weight, administered via intramuscular (IM) or intravenous (IV) injection. The treatment duration usually lasts 3–5 days, but prolonged use may be necessary in chronic cases.

Reconstitution Instructions:

Use sterile water for injection or a compatible solvent.

Shake gently to dissolve the powder completely.

Administer as directed, avoiding repeated injection in the same site to prevent tissue irritation.

Advantages of Injectable Oxytetracycline

Rapid absorption for quick therapeutic effects.

Suitable for animals that cannot take oral medication.

Long-acting formulations provide sustained drug levels.

Effective against a wide range of pathogens.

Side Effects and Precautions

While oxytetracycline is generally safe, potential side effects include:

Pain and swelling at the injection site

Gastrointestinal disturbances (if given orally)

Liver or kidney toxicity with prolonged use

Photosensitivity reactions in some animals

Contraindications:

Avoid use in animals with known tetracycline hypersensitivity.

Do not administer to pregnant animals near term (may affect fetal bone development).

Not recommended for horses with renal impairment.

Withdrawal Periods

To ensure food safety, withdrawal periods must be observed before slaughter or milk production:

Cattle: 18–28 days (meat), 4–5 days (milk)

Swine: 20–26 days

Poultry: 5–7 days

Conclusion

Sterile oxytetracycline injectable powder is a versatile and effective antibiotic in veterinary medicine. Its broad-spectrum activity, ease of administration, and rapid action make it a valuable tool for treating bacterial infections in livestock and poultry. However, proper dosage, administration techniques, and adherence to withdrawal periods are essential to ensure animal health and food safety.

Our Lifeworth as a China professional supplier & manufacturer for injectable oxytetracycline, we can we supply EP BP 99% Sterile oxytetracycline HCL injectable powder, with an annual output of more than 6000 tons, and product quality meets international standards. If you want to buy inj oxytetracycline powder, but you don’t know where to buy it, kindly contact us:sales@naturallifeworth.com, we will give you best quality, best price and best service.

Reference:

https://en.wikipedia.org/wiki/Oxytetracycline

https://pubchem.ncbi.nlm.nih.gov/compound/Oxytetracycline

Package:

1.1-5kg sample order we can provide aluminum foil bag package.

2.5-10kg order we can provide aluminum foil bag package.

3. Normally a full packge is 25kg/drum or 25kg/bag or 25kg/carton.

Contacts:

E-Mail: sales@naturallifeworth.com
Mobile: 0086-18292562757
Whatsapp: 0086-18292562757