Tell us your application, target specification, and destination market so we can support grade selection, documentation review, and packaging recommendations.

Quick Specs
Identity
Quality
Handling
Commercial Terms
MOQ
MOQ depends on packaging and specification.
Lead Time
3–7 working days for standard items; bulk orders by schedule.
Incoterms
EXW / FOB / CIF / DAP / DDP
Sample
Free sample (shipping charged)
Quality & Documents
COA (per batch) • SDS/MSDS • TDS/Spec sheet (on request). Additional statements depend on product and market.
Introduce Potassium guaiacolsulfonate
Potassium guaiacolsulfonate(Sulfogaiacol )is a pharmaceutical-grade expectorant widely used in cough relief formulations, cold preparations, and respiratory health products. Known for its ability to help loosen thick mucus and improve airway clearance, potassium guaiacolsulfonate has remained a key active ingredient in many over-the-counter (OTC) cough syrups and tablets.
What Is Potassium Guaiacolsulfonate USP?
Potassium guaiacolsulfonate (also known as Potassium guaiacol sulfonate) is a white to yellowish crystalline powder belonging to the class of expectorants. It is the potassium salt of guaiacolsulfonic acid, used primarily to help clear phlegm from the respiratory tract.
USP grade ensures the product meets strict pharmacopeia standards for safety, quality, and purity required in pharmaceutical formulations.
How Potassium Guaiacolsulfonate Works
Potassium guaiacolsulfonate is classified as an expectorant, working by:
Increasing respiratory tract secretions
It stimulates mucous membrane secretions in the bronchi.
Reducing mucus viscosity
The compound helps thin and loosen thick phlegm.
Promoting easier coughing
It enhances the expulsion of mucus, helping clear airways.
Supporting easier breathing during colds or respiratory infections
Useful in conditions where mucus buildup makes breathing uncomfortable.
Key Benefits
1.Effective Expectorant
Helps relieve chest congestion by loosening stubborn mucus.
2.Works Well in Combination Formulas
Often included with other cough and cold ingredients such as:
Dextromethorphan
Antihistamines
Nasal decongestants
Herbal cough actives
3.Fast Dissolving
Highly water-soluble, ideal for syrups and liquid medicines.
4.USP Safety Standard
Ensures high purity, minimal impurities, and guaranteed pharmaceutical quality.
5.Suitable for Various Dosage Forms
Syrups
Tablets
Granules
Capsules
Pediatric cough drops
Applications of Potassium Guaiacolsulfonate Powder
Potassium guaiacolsulfonate is widely used in:
- Cough Syrups & Expectorant Liquids
The most common application due to its excellent solubility.
- Cold and Flu Medications
Included in combination OTC formulations.
- Respiratory Support Supplements
Used in formulas aimed at improving mucus clearance.
- Veterinary Respiratory Medicines
Also used in pet and livestock respiratory health products.
- Pharmaceutical Manufacturing
As an API (active pharmaceutical ingredient) used globally.
Specifications (Typical USP Standard)
| Parameter | Description |
| Assay | ≥99% |
| Appearance | White to yellowish powder |
| Identification | Conforms to USP |
| Loss on Drying | ≤0.5% |
| Heavy Metals | ≤10 ppm |
| Solubility | Freely soluble in water |
Lifeworth — Reliable Supplier of Potassium Guaiacolsulfonate USP
Lifeworth is a professional manufacturer and global supplier of potassium guaiacolsulfonate powder, offering pharmaceutical-grade quality suitable for cough syrups, tablets and respiratory health formulations.Our company has passed the third-party audit and certification such as CQC, SGS, INTERTEK, and obtained cGMP, ISO9001, ISO14001, FSSC22000, ISO45001, BRCGS, KOSHER, HALAL and other international certifications.
We can supply 99% Potassium Guaiacolsulfonate USP powder, our annual production of Potassium Guaiacolsulfonate can exceed 2,800 tons.
We can also supply Potassium Guaiacolsulfonate, USP EP BP JP pure salicylic acid powder, 99% USP pure minoxidil raw powder, 99% bulk pure NMN powder, bulk pure glutathione powder 99%, Adenosine triphosphate powder and Raw pure bulk melatonin powder ect.Our products are exported to more than 60 countries in North America, Europe, Asia, Africa, etc. Our product capacity and quality are stable, the price is very competitive in the market, and our products are favored by customers, we Looking forward to working with you to make progress together.
If you want to buy Potassium Guaiacolsulfonate Powder, you can contact our Lifeworth: sales@naturallifeworth.com, we will give you competitive bulk price and more information, believe us, we will not let you down.

Conclusion
Potassium Guaiacolsulfonate USP is a widely used pharmaceutical expectorant valued for its effectiveness, safety, and compatibility with various cough and cold formulations. Its ability to reduce mucus viscosity and support respiratory comfort makes it an important ingredient in global OTC cough medications.
With strong manufacturing capabilities and USP-grade quality assurance, Lifeworth provides reliable bulk potassium guaiacolsulfonate powder for pharmaceutical companies, contract manufacturers, and respiratory product brands worldwide.
Reference:
https://en.wikipedia.org/wiki/Guaiacolsulfonic_acid
https://www.drugs.com/dosage/guaifenesin-potassium-guaiacolsulfonate.html
Package:
1.1-5kg sample order we can provide aluminum foil bag package.
2.5-10kg order we can provide aluminum foil bag package.
Normally a full packge is 25kg/drum or 25kg/bag or 25kg/carton.

Contacts:
E-Mail: sales@naturallifeworth.com
Mobile: 0086-18292562757
Whatsapp: 0086-18292562757
Product Overview
Applications
Technical & Formulation Notes
Technical Notes
Manufacturing & Process
Compatibility / Formulation Notes
Extended QC & Test Items
Storage, Shelf Life & Packaging
Storage
Shelf Life
Packaging & Logistics
Supply, Documentation & Customization
Documents & Compliance
COA, SDS/MSDS, and TDS/spec sheet available based on product and market requirements.
Customization & Private Label
Custom packing, private label, and labeling support available depending on product type and order scope.
Commercial Support
Sample, lead time, and incoterm options can be discussed according to destination market and supply plan.
Why Source From Lifeworth
FAQ
Need more answers?
Explore our full FAQ library for documentation, compliance, shipping, and ordering guidelines.